This paper, based on panel data of 30 provinces in China from 2010—2014, uses multiple linear regression model to study the eco-efficiency influence of different environmental regulations on different resource-dependence areas, in order to provide references for local governments to manage environment. In high resource-dependence areas, mandatory environmental regulations are negatively related to regional  eco-efficiency, market-driven and voluntary- acceptance environmental regulations show an  upside-down  U shape with  eco-efficiency. In low resource-dependence areas, mandatory environmental regulations act negatively with regional eco-efficiency, market-driven environmental regulation displays an  upside-down  U shape, but  voluntary-acceptance has little influence. Hence, the paper suggests that environmental regulations vary with the types of  resource-dependence areas at different developing stages so as to maximize the performance of environmental regulations.